Alterations in [3H]spiperone binding in human caudate nucleus, substantia nigra and frontal cortex in the Shy-Drager syndrome and Parkinson's disease
Identifieur interne : 002B82 ( Main/Exploration ); précédent : 002B81; suivant : 002B83Alterations in [3H]spiperone binding in human caudate nucleus, substantia nigra and frontal cortex in the Shy-Drager syndrome and Parkinson's disease
Auteurs : M. Quik ; G. Spokes ; A. V. P. Mackay ; R. BannisterSource :
- Journal of the Neurological Sciences [ 0022-510X ] ; 1979.
Abstract
[3H]Spiperone binding was investigated in the caudate nucleus, substantia nigra (s.nigra) and frontal cortex of control subjects and of patients with Parkinson's disease and the Shy-Drager syndrome. Binding sites for [3H]spiperone were interpreted as dopamine receptors in caudate and s. nigra, and as 5-hydroxytryptamine (5-HT) receptors in frontal cortex. Scatchard analysis showed that the Bmax (maximal number of binding sites) in caudate was similar in the 3 groups, whereas in s. nigra the Bmax was reduced by approximately 60% in both Parkinson's disease and Shy-Drager syndrome. The dissociation constant (Kd) for [3H]spiperone binding in s. nigra was similar in the 3 groups. In caudate nucleus, the Kd was similar in control and Parkinson groups; however, there was a significant increase in the dissociation constant in the caudate nucleus from cases of Shy-Drager syndrome. No differences in binding characteristics were observed in the frontal cortex. These results are taken to reflect a loss of dopamine receptor sites in the s. nigra in both Parkinson's disease and Shy-Drager syndrome, and a reduced affinity of dopamine receptor sites in the caudate nucleus in Shy-Drager syndrome.
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DOI: 10.1016/0022-510X(79)90021-2
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Bannister</name></author></titleStmt><publicationStmt><idno type="wicri:source">ISTEX</idno><idno type="RBID">ISTEX:0F81A85B52AD3D8D0D5D97DA0D1641AE9F6442A2</idno><date when="1979" year="1979">1979</date><idno type="doi">10.1016/0022-510X(79)90021-2</idno><idno type="url">https://api.istex.fr/document/0F81A85B52AD3D8D0D5D97DA0D1641AE9F6442A2/fulltext/pdf</idno><idno type="wicri:Area/Main/Corpus">001331</idno><idno type="wicri:Area/Main/Curation">001123</idno><idno type="wicri:Area/Main/Exploration">002B82</idno></publicationStmt><sourceDesc><biblStruct><analytic><title level="a">Alterations in [3H]spiperone binding in human caudate nucleus, substantia nigra and frontal cortex in the Shy-Drager syndrome and Parkinson's disease</title><author><name sortKey="Quik, M" sort="Quik, M" uniqKey="Quik M" first="M." last="Quik">M. Quik</name><affiliation><wicri:noCountry code="subField">Cambridge CB2 2QD UK</wicri:noCountry></affiliation></author><author><name sortKey="Spokes, G" sort="Spokes, G" uniqKey="Spokes G" first="G." last="Spokes">G. Spokes</name><affiliation><wicri:noCountry code="subField">Cambridge CB2 2QD UK</wicri:noCountry></affiliation></author><author><name sortKey="Mackay, A V P" sort="Mackay, A V P" uniqKey="Mackay A" first="A. V. P." last="Mackay">A. V. P. Mackay</name><affiliation><wicri:noCountry code="no comma">Address all correspondence to A. V. P. Mackay.</wicri:noCountry></affiliation><affiliation><wicri:noCountry code="subField">Cambridge CB2 2QD UK</wicri:noCountry></affiliation></author><author><name sortKey="Bannister, R" sort="Bannister, R" uniqKey="Bannister R" first="R." last="Bannister">R. Bannister</name><affiliation><wicri:noCountry code="subField">London Great Britain</wicri:noCountry></affiliation></author></analytic><monogr></monogr><series><title level="j">Journal of the Neurological Sciences</title><title level="j" type="abbrev">JNS</title><idno type="ISSN">0022-510X</idno><imprint><publisher>ELSEVIER</publisher><date type="published" when="1979">1979</date><biblScope unit="volume">43</biblScope><biblScope unit="issue">3</biblScope><biblScope unit="page" from="429">429</biblScope><biblScope unit="page" to="437">437</biblScope></imprint><idno type="ISSN">0022-510X</idno></series><idno type="istex">0F81A85B52AD3D8D0D5D97DA0D1641AE9F6442A2</idno><idno type="DOI">10.1016/0022-510X(79)90021-2</idno><idno type="PII">0022-510X(79)90021-2</idno></biblStruct></sourceDesc><seriesStmt><idno type="ISSN">0022-510X</idno></seriesStmt></fileDesc><profileDesc><textClass></textClass><langUsage><language ident="en">en</language></langUsage></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">[3H]Spiperone binding was investigated in the caudate nucleus, substantia nigra (s.nigra) and frontal cortex of control subjects and of patients with Parkinson's disease and the Shy-Drager syndrome. Binding sites for [3H]spiperone were interpreted as dopamine receptors in caudate and s. nigra, and as 5-hydroxytryptamine (5-HT) receptors in frontal cortex. Scatchard analysis showed that the Bmax (maximal number of binding sites) in caudate was similar in the 3 groups, whereas in s. nigra the Bmax was reduced by approximately 60% in both Parkinson's disease and Shy-Drager syndrome. The dissociation constant (Kd) for [3H]spiperone binding in s. nigra was similar in the 3 groups. In caudate nucleus, the Kd was similar in control and Parkinson groups; however, there was a significant increase in the dissociation constant in the caudate nucleus from cases of Shy-Drager syndrome. No differences in binding characteristics were observed in the frontal cortex. These results are taken to reflect a loss of dopamine receptor sites in the s. nigra in both Parkinson's disease and Shy-Drager syndrome, and a reduced affinity of dopamine receptor sites in the caudate nucleus in Shy-Drager syndrome.</div></front></TEI><affiliations><list></list><tree><noCountry><name sortKey="Bannister, R" sort="Bannister, R" uniqKey="Bannister R" first="R." last="Bannister">R. Bannister</name><name sortKey="Mackay, A V P" sort="Mackay, A V P" uniqKey="Mackay A" first="A. V. P." last="Mackay">A. V. P. Mackay</name><name sortKey="Quik, M" sort="Quik, M" uniqKey="Quik M" first="M." last="Quik">M. Quik</name><name sortKey="Spokes, G" sort="Spokes, G" uniqKey="Spokes G" first="G." last="Spokes">G. Spokes</name></noCountry></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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